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This journal requires that writers assign a level of evidence to every article. For a complete description among these Evidence-Based Medicine reviews, please relate to the Table of Contents or even the web Instructions to Authors www.springer.com/00266 .Classic telemonitoring when it comes to detection of arrhythmias is more developed. The arrival of wearable ECG devices is connected with great potential and significant challenges. New informa

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the degradation products of beta-amyloid. We have analyzed several issues which could be critical for understanding the pathogenesis of Alzheimer's disease, specifically 1) the need for a negatively charged membrane to produce the ion channel; 2) the potential role of the aggregated form in cellular toxicity of Aβ peptides; 3) channelforming ability of multiple degradation products of amyloid; 4) non-specificity of ion channels formed by amyloid peptides. Potential targets of channel-forming oligomers appear to be intracellular and ar