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Overall, the present study demonstrates that the J/T@8P4s can be a promising therapeutic treatment against the PDAC via suppression of SE-associated oncogenic transcription, and provides a strategy utilizing NPs to assist the drug delivery targeting SEs. © 2020 The Authors. Published by WILEY‐VCH Verlag GmbH Co. KGaA, Weinheim.Tin selenide (SnSe) is one of the most promising candidates to realize environmentally friendly, cost-effective, and high-performance thermoelectrics, derived from its outstanding electrical transport prope