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This detailed investigation substantiated a reversible binding and mixed MAO-B catalytic function inhibition via sesamin (Ki 0.473 ± 0.076 μM). Selectivity and reversibility of sesamin on MAO-B provide exciting prerequisites for further in vivo investigation to confirm its therapeutic potentiality. © 2020 The Author(s).Thymoquinone is the most biologically active constituent of Nigella sativa (black seed). A monoterpene compound chemically known as 2-methyl-5-isopropyl-1, 4-quinone. In this study, the gender-depende
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