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, temperature-responsive) into a pre-cooling and material cation containing coagulation shower. Experimental results indicate the fiber microstructure could be controlled because of the extrusion rate and air conditioning temperature, achieving an anisotropic shrinking characteristic and unique grooved/wrinkled area habits. Significantly, the integration of material cations (e.g., Ca2+and/or Zn2+) had been verified to considerably improve hydrogel mechanical properties (i.e., two fold companies) and enha