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These results suggested the better outcome in the treatment for the patients with TTP in the near future.The supplementation of factor (F-) VIII or F-IX products for hemophilia treatment has helped in preventing arthropathy and considerably improving the quality of life (QOL) of patients. However, serious issues related to hemostatic treatment of hemophilia include the need for repeated intravenous infusion of products, inhibitor development, and hemostatic treatment for patients with inhibitors. To overcome these issues, some ex