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This was the first study of its kind to concurrently measure peak and cumulative spinal moments and their relationship to systemic inflammation in both sexes, while strictly controlling for confounding variables (e.g. physical activity, caloric intake, body composition, etc.). Greater levels of IL-6 and IL-8 were seen in the LFHR condition, likely due to the greater cumulative spinal moments in this condition. This was the first study of its kind to concurrently measure peak and cumulative spinal moments and their relationship to system