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Drug safety research asks causal questions but relies on observational data. Confounding bias threatens the reliability of studies using such data. The successful control of confounding requires knowledge of variables called confounders affecting both the exposure and outcome of interest. However, causal knowledge of dynamic biological systems is complex and challenging. Fortunately, computable knowledge mined from the literature may hold clues about confounders. In this paper, we tested the hypothesis that incorporating literature-der