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Background The diagnostics of primary aldosteronism (PA) are usually carried out in patients taking antihypertensive medications. We compared hemodynamics between medicated PA, medicated essential hypertension (EH), never-medicated EH, and normotensive controls (n=130 in all groups). Methods The hypertensive groups were matched for age (53 years), sex (84 male/46 female), and body mass index (BMI) (30 kg/m2 ); normotensive controls had similar sex distribution (age 48 years, BMI 27 kg/m2 ). Hemodynamics were recorded using whole-body i