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Finding the Best ADHD Medication For Adults Many adult ADHD treatment plans are based on medication. However, finding the right medication and dosage isn't always easy. Stimulants: These medications are used to treat both hyperactivity and inattention. They work by increasing the levels of chemicals in the brain that pass messages between nerve cells. They are taken several times throughout the day and start working in under an hour. Stimulants Most doctors begin with stimulants to treat ADHD