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On the basis of the comparable increasing incidence of oral tongue SCC (OTSCC) and oropharyngeal SCC (OPSCC) in ladies and males respectively, we hypothesize that changes in sexual habits can result in a growing occurrence of herpesvirus when you look at the mouth, especially HSV-2, much like exactly what was already explained in HPV-positive OPSCC. Because viral genome integration has not been recognized in OSCC from NSND, a "hit and operate" viral apparatus involving epigenome deregul

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