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Background Nitrous oxide may be misused due to its euphoric, dissociative, and hallucinogenic effects. Nitrous oxide misuse has been reported to be increasing.Objective The objective of this study is to describe nitrous oxide misuse reported to two United States (US) data systems.Methods Cases were nitrous oxide misuse during 2000-2019 reported to the National Electronic Injury Surveillance System (NEISS), which collects data on consumer product-related injuries treated in US emergency departments (EDs), and the Food and Drug Administra