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001), CEA ( = 0.015), and GPS 1 (HR; 2.095, 95% CI; 1.025-4.283; = 0.043) and 2 (HR, 2.812; 95% CI, 1.111-7.116; = 0.029) as independent prognostic factors; however, mGPS and HS-mGPS were not independent prognostic factors for CSS. Log-rank tests demonstrated significant differences in OS among patients with GPS 0 vs. 1 ( 0.001) and 0 vs. 2 ( 0.001) and in CSS among the three GPS (0 vs. 1; = 0.005, 0 vs. 2; 0.001, 1 vs. 2; = 0.009). GPS most reliably predicts long-term survival of gastric cancer patients. GPS most reliably predicts long-term