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Analysis of community-wide phenotypes unveiled a succession from cardiovascular bacteria and anaerobic bacteria to facultative anaerobes, and from Gram-negative to Gram-positive types during instinct microbiota development at the beginning of childhood. The metabolic functions for the gut microbiome shifted tremendously alongside early physiological development, including an increase in alanine, aspartate, and glutamate metabolic rate, and a reduction diarrhoea. Copyright © 2020 Niu, Xu, Qian