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Finally, current challenges toward clinical translation with an emphasis on innovative design strategies and future striving directions are rationally discussed. This comprehensive and detailed Review provides a deep understanding of the current research status of melanin-like nanomaterials and is expected to motivate further optimization of the design of novel tailorable and marketable multifunctional nanoplatforms in biomedicine. © 2020 The Authors. Published by WILEY‐VCH Verlag GmbH Co. KGaA, Weinheim.A highly selective and se