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67 [0.52; 0.84], p=0.001), and pH (OR 0.15 [0.02; 1.04], p=0.05). By using a receiver operating characteristic curve analysis, hemoglobin level below 9 g dl-1, fibrinogen level below 2 g l-1, pH below 7.12 and BMI below 25 were identified to predict early major bleeding events. Major bleeding events were independently associated with mortality (OR 2.54, CI 95% [1.38; 4.66], p=0.01). CONCLUSIONS We found that post-cardiotomy VA ECMO, hemoglobin levels below 9 g dl-1, fibrinogen levels below 2 g l-1, pH below 7.12 and BMI below 25 were as

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09 to 9.32 fL, P = 0,004). CONCLUSION MPV can be used as a predictor of early response to the first line treatment in newly diagnosed adult primary ITP patients.BACKGROUND Heroin can be detected and quantified by certain analytical methods; however, forensic professionals and criminal laboratories study for cheaper and faster detection tools. Surface-enhanced Raman spectroscopy rise as a possible alternative tool with their widening application spectra. There are few studies regarding Raman and SERS spectra of heroin and its metabolites, which