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HK-2 cells were split into five teams empty control group, design group, DSS-L, DSS-M, DSS-H, according to the matching drug and dosage of each therapy group. Protein and mRNA levels of Jagged1, Notch1, Hes5, Notch intracellular domain (NICD), E-cadherin, alpha-smooth muscle mass actin (α-SMA) and vimentin at 24h, 48h and 72h were detected by west Blot and RT-qPCR. OUTCOMES The necessary protein and mRNA degrees of Jagged1, Notch1, Hes5, NICD, α-SMA and vimentin in treatment groups wer
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