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461, P.001). Multivariate analysis performed in separate models demonstrated sex, CAD, LDL, and SII levels (Odds ratio [OR] 1.004, 95 CI%1.003-1.004) as independent predictors of severe AS in Model 1. According to Model 2, sex, CAD, LDL, and high SII (661) (OR5.78, 95 CI%3.93-4.89) remained as independent predictors of severe AS. SII levels can be useful to predict severe calcific AS patients and significantly correlate with AVA and mean aortic transvalvular pressure gradient. SII levels can be useful to predict severe calcific