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We additionally noticed much more prominent EM48-positive mutant huntingtin aggregates when you look at the method spiny neurons associated with high dosage of AAV2-82Q injected group. Conclusion Based on the results from the current research, high dose of AAV2-82Q is the maximum titer for establishing a Huntington rat design. Delivery of large dosage of human AAV2-82Q led to the manifestation of Huntington behaviors and maximum phrase associated with the huntingtin protein i
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