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Although plenty of treatment modalities have been tried, none has been proven unequivocally efficacious. Apart from information and education, which should be offered to all patients, the most effective pharmacological treatments seem to be bisphosphonates, glucocorticoids and vasoactive mediators, while physical therapy and rehabilitation therapy also make part of the treatment. © 2019 The Mediterranean Journal of Rheumatology (MJR).Stroke is a major cause of morbidity, mortality and disability in systemic lupus erythematosus (SLE).