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Therefore, a novel positive CPP carrier of P9 was developed to improve CPP-PTX affinity via a double-proline (Pro, P) hairpin tail and enhance PTX translocation through the decrease in translocation energy barrier, verified by the MM-PBSA analysis and umbrella sampling simulation. Cellular uptake study shows that P9 can easily translocate in to the HeLa cells within 1 min and shows no noticeable cytotoxicity. Contrasted to R7, P9 is able to help PTX translocation, ultimately causing an extraordinary upsurge i
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