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Adult ADHD and Comorbid Disorders Many adults suffering from ADHD also have comorbid disorders, such as major depressive disorder (Kessler and colleagues, 2006). Many patients do not respond to medications for depression and may benefit from psychotherapy. Medications that most effectively improve core symptoms of ADHD seem to boost and regulate levels of certain neurotransmitters, which are brain chemicals. The most frequently prescribed stimulants include methylphenidate, amphetamine a