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The Brier score (BS) was used to quantify overall performance of the selected model. The logistic regression model using the mutualinformation (MI) dimensionality reduction method was final selected with an AUC value of 0.79 for the training set and 0.73 for the external validation set to predicting MSI. The BS value of the model was 0.12 in the training set and 0.19 in the validation set. The established combined radiomics model has the potential to predict MSI status in CRC patients preoperatively. The established combined radiomics model has the