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Compromised autophagy and mitochondrial dysfunction downregulate chondrocytic activity, accelerating the development of osteoarthritis (OA). Irisin, a cleaved form of fibronectin type III domain containing 5 (FNDC5), regulates bone turnover and muscle homeostasis. Little is known about the effect of Irisin on chondrocytes and the development of osteoarthritis. This study revealed that human osteoarthritic articular chondrocytes express decreased level of FNDC5 and autophagosome marker LC3-II but upregulated levels of oxidative DNA damage ma

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A 2 in 1 Stroller With Car Seat Is a Convenient Choice A 2-in-1 stroller with car seat is a great option that can save your time and energy. With so many options available, it can be hard to decide which one is best for your family. Review features and compare features to find the right car seat stroller for you. Spend time with your little one and make your travels easier. Easy to Assemble The most effective stroller and car seat combos are simple to put together, attach to the vehicle and th