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Although risk facets have now been extensively talked about within the literary works, the part associated with DNA mismatch repair system continues to be unanswered. To guage the influence associated with the DNA mismatch repair (MMR) protein immunostaining on the tumor progression and prognosis of oropharyngeal squamous mobile carcinoma (OPSCC). This retrospective observational research made up 50 cases of OPSCC. Immunohistochemistry for MSH2, MSH6, PMS2