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DKK 1 contributes to the development of osteolytic lesions in MM. The present study provides morphological evidence that inhibition in Wnt signaling may lead to bone damage observed in the advanced stage of the disease. To determine the content of low-spin form of cytochrome P450in primary tumors and liver metastases of the patients with metastatic colorectal cancer (mCRC) and and assess its prognostic significance. The levels of the oxidized and low-spin forms of cytochrome P450in the tissues of patients with mCRC were studied by electron paramagnetic reso