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02; PFS P=.003). Additionally, all 3 patients with TP53 mutation co-occurring with PIK3CA mutation (2 of 8 patients) or RB1 mutation (1 of 8 patients) responded to anti-PD-1 therapy. Anti-PD-1 therapy was effective regardless of PD-L1 positivity in patients with advanced LCNEC. Our investigation might suggest that the density of tumoral CD8-positive TILs and the presence of co-occurring mutations are predictors of the efficacy of anti-PD-1 therapy in patients with advanced LCNEC. Anti-PD-1 therapy was effective regardless

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Non Electric Treadmill Reviews A non-electric treadmill lets you to choose your pace, which can be a great workout for HIIT. According to a study conducted in 2021, it may also aid runners in understanding the speed at which they can run the fastest. is. Non-motorized treadmills that have a curve tend to be newer on the market and generally cost more. They are less entertaining and have fewer programs built in however they last longer than motorized models. Choosing the Best T