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isk parameters and that many men may be safely monitored with a substantially less intensive surveillance regimen. In this study, among men with low-risk prostate cancer, heterogeneity prevailed in risk of subsequent disease reclassification. These findings suggest that active surveillance intensity can be modulated based on an individual's risk parameters and that many men may be safely monitored with a substantially less intensive surveillance regimen. Novel approaches are needed to improve outcomes in patients with squamous cell