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21vs 0.21, p=0.0007). Participants in the lowest CC16 and highest inflammation tertile had the highest odds for having LLF (p0.0001 for comparison with participants in the highest CC16 and lowest inflammation tertile). Among seven SNVs associated with circulating CC16, the top SNV rs3741240 was associated with decline of FEV /FVC and, marginally, FEV (p=0.003 and 0.025, respectively; N=611 participants, 20,801 lung function observations). Serum CC16 deficits are strongly associated with severity of CF lung disease and their effects ar
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