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Besides, both Fe-HCl-NH2-UiO-66 NPs and Fe-Ac-NH2-UiO-66 NPs exhibit lower Michaelis-Menten constants (Km) for hydrogen peroxide (H2O2) than most reported nanomaterials, indicating their higher affinity to H2O2. Due to their excellent catalytic activity to low concentration of substrates, Fe-HCl-NH2-UiO-66 NPs can detect H2O2 with a limit of detection (LOD) of 1.0 μM. Thus, our system can be used to detect the low cellular H2O2 concentration. With high peroxidase-like activity induced by plenty of single atom Fe(Ⅲ) sites, Fe-HCl-NH2-UiO-
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