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n by "route of administration," with patients strongly preferring oral administration. Atrial cardiopathy and likely pathogenic patent foramen ovale (PFO) are two potential embolic sources in patients with embolic stroke of undetermined source (ESUS). The relationship between these two mechanisms among ESUS patients remains unclear. Atrial cardiopathy was defined as increased left atrial diameter index ( 23 mm/m ) or left atrial volume index ( 34 mL/m ), or PR prolongation (≥ 200 ms), or presence of supraventricular extrasysto
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