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002 and p0.001, respectively), but not in males. These findings revealed a female-specific effect of COMT rs4680 on the relationship between executive dysfunction and PLEs in young adults. These findings revealed a female-specific effect of COMT rs4680 on the relationship between executive dysfunction and PLEs in young adults.Parkinson's disease (PD) is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the nigrostriatal pathway. Although the exact mechanisms underlying PD are still not com