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This study aimed to evaluate cognitive function in patients with anxious depression. This was a part of the "Objective Diagnostic Indicators and Individualized Drug Intervention of Major Depressive Disorder (MDD)" study. All participants, including patients with MDD and healthy controls (HCs), completed the 17-item Hamilton Depression Scale (HAMD ) and the Hamilton Anxiety Scale (HAMA). Anxious depression was defined as a HAMD anxiety/somatization factor score ≥7. Cognitive function was assessed at baseline and at the end of week 8. HC cog