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Through an original "hot ions effect", produced by the heating of Cu ions through the photothermal aftereffect of the composite hydrogel, the hydrogel revealed high-efficiency, quick, and long-lasting inhibition of methicillin-resistant Staphylococcus aureus and Escherichia coli. In inclusion, the hydrogel possessed remarkable bioactivity to stimulate angiogenesis. The in vivo results verified that the "hot ions effect" regarding the composite hydrogel eliminated existing infection when you