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LncRNA HULC silencing had opposite effects on the tubular formation, invasion, and EMT process as well as tumor growth of GBM cells. LncRNA HULC stimulates the EMT process and VM in human GBM, and may be a therapeutic target for intervention of GBM. LncRNA HULC stimulates the EMT process and VM in human GBM, and may be a therapeutic target for intervention of GBM. The objective of this systematic review was to describe studies that report on whether surface characteristics such as electrostatic charge, surface free energy, and surface t