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omic aberrations of primary breast cancers were associated with time to relapse. Primary tumors and matched recurrences showed a core of shared driver genomic aberrations but private actionable alterations have been identified in the relapses. Specific genomic aberrations of primary breast cancers were associated with time to relapse. Primary tumors and matched recurrences showed a core of shared driver genomic aberrations but private actionable alterations have been identified in the relapses.The comorbidities of depression and chron

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ble by careful monitoring. Recent discontinuation of HCQ from at least four large studies effectively marks the end of efforts at repurposing of CQ or HCQ for COVID-19 infection. This episode leaves behind important questions on dose selection and risk/benefit balance in repurposing drugs generally. The optimal ulcerative colitis biopsy protocol is unclear. To evaluate the number of biopsies required to accurately assess microscopic disease activity in ulcerative colitis METHODS Biopsies from patients with ≥4 rectosigmoid samples, and