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Medication For ADHD - What Are the Side Effects? Many people who suffer from ADHD experience a reduction in symptoms when they take medication. Every person's reaction is different, and the side effects are sometimes problematic. Methylphenidate is a stimulant. It works by increasing levels of a chemical in the brain that helps control the attention span and behavior. Stimulant medications Stimulant medication can improve concentration and attention for 70 to 80% children and adults that use it. They work by altering neurotransmitters, such as norep