https://diaz-castillo-3.federa....tedjournals.com/is-c
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https://www.selleckchem.com/pr....oducts/ac-devd-cho.h
BACKGROUND AND PURPOSE Increasing evidence has indicated that the high risk of cardiovascular disease in chronic kidney disease (CKD) patients cannot be sufficiently explained by classic risk factors. EXPERIMENTAL APPROACH Based on the least absolute shrinkage and selection operator method, we identified significantly altered renal tissue metabolites during progressive CKD in a 5/6 nephrectomised rat model and in CKD patients. KEY RESULTS Six aryl-containing metabolites (ACM) were significantly increased from week 1 to week 20. They