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This article summarizes recent advances in the use and understanding of stem cell-derived ECMs. Moreover, future directions to extend the spectrum of applications of stem-derived ECMs in tissue engineering by comprehensively elucidating and engineering their regulatory function is highlighted.Background. Siponimod, interferon beta-1a (IFN ß-1a), IFN ß-1b, and natalizumab have been evaluated as treatments for secondary progressive multiple sclerosis (SPMS) in separate randomized controlled trials (RCTs), but not head-to-head. These tria
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