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brucei are highlighted. Additionally, the advantages of metabolomics, alone or combined with other methods, are discussed. Compared to other parasites, only few studies employing metabolomics have to date been reported on Trypanosoma brucei. Published metabolic studies, treatments and modes of action are discussed. The main interest is to evaluate the metabolomics contribution to the understanding of T. brucei's metabolism. Compared to other parasites, only few studies employing metabolomics have to date been reported on Trypanosoma bruc