https://www.selleckchem.com/sc....reening/fda-approved
To evaluate microbial and host-derived biomarker changes during experimental peri-implantitis in the Beagle dog. Limited data exist on the microbial and biomarker changes during progressive bone loss as result of experimental peri-implantitis. In total, 36 implants (n =6) were assessed over 3 episodes of ligature-induced peri-implantitis followed by a period of spontaneous progression. Implants with hybrid (H) and completely rough (R) surface designs were used. Clinical and radiographic parameters were recorded at 4 t