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112, p0.001; women β=0.060, p=0.011) and SUA (men β=-0.282, p0.001; women β=0.317, p0.001) were significantly and independently related to eGFR. Further, the interactive relationship between alcohol consumption and SUA (men F=6.388, p0.001; women F=5.368, p0.001) was a significant and independent indicator of eGFR. These results suggested that alcohol consumption and SUA were synergistically associated with renal dysfunction among community-dwelling persons. These results suggested that alcohol consumption and SUA we