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The bioavailability of this ingredient had been increased by an issue of 13 in a simulated human gastrointestinal system in comparison with free annonacin and an encapsulation efficiency of 35% had been achieved. In addition, the cytotoxic activity of SMPMs that hosted annonacin (100 µM, 24 h, 5.8% live cells) had been increased in contrast to no-cost annonacin in water (100 µM, 24 h, 92% live cells). These outcomes highlight the employment of