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Hypobaric hypoxia (HH) during flight might be more detrimental to pulmonary circulation in Fontan patients compared healthy individuals. This study was designed to clarify whether exercise-induced hypoxia could predict HH during flight in Fontan patients. Percutaneous oxygen saturation (SpO ) was analyzed during flight in 11 Fontan patients and eight volunteers. SpO was measured before taking off (S1), at the initial (S2), the end of stabilization (S3), and after landing (S4). The SpO -dynamics were compared with SpO -dynamics during card