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Importantly, the exaggerated inflammatory response in GR mice also enhanced associated tumorigenesis, resulting in a higher number and larger size of tumors in the colon. Our results reveal an important role of intestinal epithelial cells as targets of glucocorticoid action in inflammatory bowel disease and suggest that the efficacy with which colitis is kept at bay directly affects the progression of colorectal cancer. Our results reveal an important role of intestinal epithelial cells as targets of glucocorticoid action in inflammatory b