Causes of Truck Crash Accidents When a truck crash happens, the driver may be at fault, but there are many other factors that could contribute to an accident. Some of the most common causes are fatigue of the driver, Impaired driving, and a truck loaded with hazardous cargo. Companies that manufacture such equipment may also be held liable for damages. If you suffer injuries or injuries, seek medical treatment as soon as you can. Record evidence of the crash and exchange information with the other parties. Request a copy of the police report.