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John Ioannidis writes about the harm caused by misinformation about COVID-19.1 We draw from communication research to offer best practices for reducing misinformation, disseminating accurate health information, and promoting prevention and control recommendations. We recommend three strategies that medical, public health, and scientific professionals working with government officials, clinicians, media commentators, and in other contexts around the world can use to improve communication about outbreaks. This article is protected by cop