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This study contributes to the investigation of immune mechanisms and identifies more effective targets for immunotherapy of OV.Fibrosis is a chronic and progressive disorder characterized by excessive deposition of extracellular matrix, which leads to scarring and loss of function of the affected organ or tissue. Indeed, the fibrotic process affects a variety of organs and tissues, with specific molecular background. However, two common hallmarks are shared the crucial role of the transforming growth factor-beta (TGF-β) and the involvement