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We suggest placing emphasis on the use of therapeutic drug monitoring and dose individualization when optimizing therapy in these settings.The initial nucleation of adsorbed carbon (-C) and hydrocarbon groups (-CH,-C2H2,-CH2 and -CH3) on Ir, Pt, Au, Rh, and C1 0 surfaces are investigated for diamond heteroepitaxial. It is revealed that the carbon-hydrogen ratios of the adsorbed species play a key role The relative stabilities of these species vary while the coverage increases; at full coverage, only -C2H2 is favorable on the surf