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The effect of imputing missing data followed by propensity score analysis on the incremental cost-effectiveness ratio (ICER) in a cost-effectiveness analysis is unknown. The objective was to compare alternative approaches in grouping data following imputation and prior to calculating propensity scores for use in economic evaluation. Patient-level data from an observational study of 573 children with Crohn's disease were used in a microsimulation model to determine the incremental cost of early anti-tumor nec

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06) increased the care load. In multipl linear regression analysis, age (p=0.03), COPD assessment test (CAT) score (p=0.001), FEV1%(0.068) and the number of comorbidities of patients (p=0.01) and the number of comorbidities of caregivers (p=0.003) increased the caregiving burden. In COPD increases caregiving burden. This burden is greater in symptomatic patients and when comorbidities are present. Psycho-social and legal regulations should be investigated and solutions should be produced for the caregivers of COPD patients. In COPD