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Metagenomic sequencing was used to reveal the dynamic changes in microbiota and the metabolic functions in corncob composting for preparing cultivation medium of Pleurotus ostreatus. Results showed that the changes of physicochemical properties lead to different dominant phylum at different stages of composting. Firmicutes replaced Proteobacteria as the dominant phylum at thermophilic stage. Correlation analysis indicated that the succession of microbiota was significantly affected by the C/N ratio, pH, temperature and organic matters

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ions to support patients' needs and preferences proves effective to ensure a good long-term adherence to SLIT in real-life. The Italian Registry on Severe Asthma (IRSA) is the most recent and largestregistry in Italy. To improve the knowledge on the clinical and biological features of severe asthma (SA), and to monitor its treatments. To analyze clinical,functional, inflammatory, and treatment characteristics of severe asthmatics from the IRSA registry. 851 subjects were enrolled. 31.8% and 64.5% of patients were